Conditions for keeping VidPrevtyn once mixed | Primary care latest updates

Sent on behalf of Dr Tim Davies and CARS 

We have been asked for clarity about the conditions within which VidPrevtyn Beta needs to be kept once it has been mixed. A number of sources (SPC, Green Book, e-Learning package, SPS website) all say things that could be interpreted as subtly different. I have been in contact with both UKHSA and NHS England national team and have been advised that the following advice is acceptable:

Once mixed, VidPrevtyn Beta can be kept for a maximum of 6 hours, after which it must be discarded.

If it is being used in a typical clinic setting (for example within a 2-3 hour period) it is acceptable for it to be left out of the fridge during that time.

If the vaccine is to be used over a more protracted time (up to the 6 hour maximum) then it should be placed back in to storage at 2-8 degrees for the periods of inactivity.

If it is unavoidable to keep the vaccine at room temperature for the full 6 hours then there is no need to discard the vaccine earlier than 6 hours and any vaccines given within that period will be acceptable. However, this is not best practice, and the expectation should be that where vaccine will be used over an extended period, up to the 6 hour limit, that it will be kept at 2-8 degrees during periods of inactivity. This may be by utilising a fridge or an appropriate cool box for domiciliary services.